Acute gouty flare is a serious debilitating condition causing excruciating pain with an unmet medical need. Despite several drugs on the market to manage chronic gout prophylactically, patients still suffer on average, three acute gout flare-ups every year that last for 5-7 days. Acute gouty flare is an intensely painful and disabling inflammatory arthritis, usually involving a single joint but occasionally involving two or more joints. Without therapy, the gout flare usually lats a few days to several weeks, particularly in early disease. Symptoms do improve quickly with administration of NSAIDs, Steroids, or Colchicine. However, all of these drugs have significant systemic side effects that make these drugs less desirable and poorly tolerated.